Hydrodynamically Balanced Gastro-retentive Drug Delivery Systems ab 49 EURO Effect of Excipients and Processing Parameters
The drugs incorporated in controlled release drug delivery systems shows variations in bioavailability due to their selective absorption from specific part of stomach and upper gastro-intestinal tract. In this book, various gastro-retentive approaches have been described for increasing therapeutic performance of drugs having absorption potential from stomach. A major focus has been given on the hydrodyanamically balanced systems, its formulation aspects and effects of excipients and processing parameters. The various types of gastro-retentive drug delivery systems have been well illustrated with diagrammatic illustrations wherever necessary. Also major attention has been given on evaluation of these drug delivery systems. The currently available gastro-retentive drug delivery systems in market have been described. The future potentials of these drug delivery systems have been presented. This book will be useful for the students at graduate level, post graduate students and research scholars for understanding the basics of gastro-retentive drug delivery systems.
Oral drug delivery system represents one of the frontier areas of controlled drug delivery system. Such a dosage forms having a major advantage of patient compliance. Floating drug delivery system belongs to oral controlled drug delivery system group which are capable of floating in the stomach by bypassing the gastric transit. These dosage forms are also defined as Gastro Retentive drug delivery System or hydrodynamically balanced dosage form or gastric floating drug delivery system, which can float in the contents of the stomach and release the drug in a controlled manner for prolonged period. The release rate will be controlled depending upon the type and concentration of the polymer which swells, leads to diffusion and erosion of the drug. Despite tremendous advancement in drug delivery, oral route of administration has received the more attention and success because the gastrointestinal physiology offers more flexibility in dosage form design than other routes. Hence, research continuously keeps on searching for ways to deliver drugs over an extended period of time, with a well-controlled release profile.